Enamel Matrix Derivative and TGF-Beta 1 Target Genes in Human Tongue Carcinoma Cells
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چکیده
منابع مشابه
Enamel matrix derivative gel stimulates signal transduction of BMP and TGF-{beta}.
It has been shown that Emdogain Gel (Emd-Gel) containing enamel matrix proteins promotes biomineralization, such as osteogenesis and cementogenesis, during the regeneration of periodontal tissues. However, the growth factors involved in these activities of Emd-Gel remain unclear. In this study, Emd-Gel was fractionated into 22 sub-fractions by size exclusion chromatography. The osteoinductive f...
متن کاملEnamel matrix derivative stimulates human gingival fibroblast proliferation via ERK.
Emdogain, a formulation of Enamel Matrix Proteins, is used clinically for periodontal regeneration to stimulate PDL (periodontal ligament), cementum, and bone formation. Its effects on gingival fibroblasts and tissue have not been thoroughly studied. Therefore, we investigated the mechanisms by which Emdogain affects the cell cycle of human gingival fibroblasts. Without serum, Emdogain (50 micr...
متن کاملEffects of enamel matrix derivative and transforming growth factor-β1 on human osteoblastic cells
BACKGROUND Extracellular matrix proteins are key factors that influence the regenerative capacity of tissues. The objective of the present study was to evaluate the effects of enamel matrix derivative (EMD), TGF-β1, and the combination of both factors (EMD+TGF-β1) on human osteoblastic cell cultures. METHODS Cells were obtained from alveolar bone of three adult patients using enzymatic digest...
متن کاملRoot coverage technique with enamel matrix derivative.
Various periodontal plastic surgical techniques are employed in obtaining root coverage. Recently, the use of an enamel matrix derivative (EMD) has been reported in such treatment. We report 2 cases of root coverage surgery with a coronally positioned flap in combination with EMD (CPF+EMD) and connective tissue graft in combination with EMD (CTG+EMD). Case 1: The patient was a 25-year-old woman...
متن کاملThe Use of Enamel Matrix Derivative
Background—Periodontal disease results in the loss of the attachment apparatus. In the last three decades, an increasing effort has been placed on seeking procedures and materials to promote the regeneration of this tissue. The aim of this paper is to evaluate the effect of enamel matrix derivative (EMD) during regenerative procedures. In addition, a meta-analysis is presented regarding the cli...
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ژورنال
عنوان ژورنال: Dental Oral Biology and Craniofacial Research
سال: 2020
ISSN: 2613-4950,2613-4950
DOI: 10.31487/j.dobcr.2020.06.05